Fig. 6. a) Binding of SKA-111 (yellow) in the calmodulin (CaM, orange red) binding region of the K_Ca3.1 (pink) homology model provided by Brown et al. [157]. b) Overlay of CaM binding regions of K_Ca3.1 homology model and cryo-EM structure. c) CaM (kakhi) binding to the CaM binding region of the later solved cryo-EM K_Ca3.1 structure (pdb 6cno [3]).